Most protein based biological processes proceed within a narrow range of optimal conditions (temperatures, redox states, etc.) outside of which efficiency steeply declines and damage can occur. Despite this, organisms have evolved to adapt to an amazing range of environmental extremes. The broad research interests of the lab lie in understanding how organisms adapt to extreme environments, with the goal of exploiting any insights we may gain to intervene in the devastating degenerative processes that occur in disease and during aging. For this we use the model organism C. elegans and cultured mammalian cells to examine the physiological, behavioral and transcriptional responses to stress.
Seeking postdocs and graduate students!
Current projects in the lab are:
Investigating the molecular mechanisms by which neurons control the stress response of organism
- How does stress change neuronal activity?
- Does neuromodulation co-opt different circuits to respond to stress?
- How does neuronal activity modulate gene expression?
- What role does stress-induced transcription by the transcription factor heat shock factor 1 (HSF-1) play in neuronal responses to stress?
Investigating how the innate immune response modulates mitochondrial homeostasis
- What are the common players between pathogen-induced innate immunity and mitochondria-induced innate immunity?
- Does immunosenescence modulate mitochondiral health?
- Do disease associated metastable proteins influence the immune response?
If you are interested in learning more about our research or joining the lab, please CONTACT US
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