Most protein based biological processes proceed within a narrow range of optimal conditions (temperatures, redox states, etc.) outside of which efficiency steeply declines and damage can occur. Despite this, organisms have evolved to adapt to an amazing range of environmental extremes. The broad research interests of the lab lie in understanding how organisms adapt to extreme environments, with the goal of exploiting any insights we may gain to intervene in the devastating degenerative processes that occur in disease and during aging. For this we use the model organism C. elegans and cultured mammalian cells to examine the physiological, behavioral and transcriptional responses to stress.
Current projects in the lab are:
Investigating the molecular mechanisms by which different cells and tissues in an organism respond to stress
Investigating how mitochondrial dysfunction and the innate immune response pathway modulate neuronal health and degeneration
If you are interested in learning more about our research or joining the lab, please CONTACT US
To learn more read on.......